The multiple effects of ketamine on the electroencephalographic activity in wag/rij rats
| Autor: | Mydzianovskaya, I.S., Salonin, D.V., Bosnyakova, D.Y., Kuznetsova, G.D., Luijtelaar, E.L.J.M. van, Coenen, A.M.L., Chepurnov, S.A. |
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| Přispěvatelé: | Luijtelaar, E.L.J.M. van, Kuznetsova, G.D., Coenen, A.M.L., Chepurnov, S.A. |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers, 163-178. Nijmegen : NICI STARTPAGE=163;ENDPAGE=178;TITLE=Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers, pp. 163-178 |
| Popis: | Item does not contain fulltext The effects of ketamine, a non-competitive antagonist at the NMDA receptor, were studied on the EEG in a genetic animal model of generalized absence epilepsy - the WAG/Rij rat strain. Animals of this strain display spontaneous occurring generalized spike-wave discharges (SWDs) in EEG. Ketamine was administered i.p., in a dose of 3, 6, 15 and 30 mg/kg. Biphasic effects of ketamine were observed. The first phase was a dose-dependent suppression of SWDs, followed by a second phase characterized by the facilitation of SWDs. This increase of the discharges was expressed first as an increased number of SWDs, and later on as a significant prolongation of individual discharges. An obvious amplitude modulation of the discharges in this period was also found. During the period of suppression of spike-wave activity, a new phenomenon was observed: quasi-periodic groups of spikes or wave-spikes, with an internal frequency of 4 - 5 Hz and a periodicity of about 5 seconds. That quasi-periodic activity vanished few minutes prior to the recovery of the classical SWDs. However, a specific 5 second amplitude modulation of SWDs remained also in the recovery period. The propensity of that specific ketamine-induced activity was found to be correlated with propensity of SWDs in background EEGs of drug-free animals. It can be concluded that ketamine has more effects on the EEG than previously assumed which cannot be explained by a simple blockade of the NMDA receptor. It is also thought that the obtained specific dynamics of SWDs' frequency may be caused by changes in the activity of the thalamo-cortical pacemaker that is generating SWD. |
| Databáze: | OpenAIRE |
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