Normal range for MR elastography measured liver stiffness in children without liver disease
| Autor: | Sawh, Mary Catherine, Newton, Kimberly P, Goyal, Nidhi P, Angeles, Jorge Eduardo, Harlow, Kathryn, Bross, Craig, Schlein, Alexandra N, Hooker, Jonathan C, Sy, Ethan Z, Glaser, Kevin J, Yin, Meng, Ehman, Richard L, Sirlin, Claude B, Schwimmer, Jeffrey B |
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| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Adult Chronic Liver Disease and Cirrhosis Medical and Health Sciences Oral and gastrointestinal hepatic shear stiffness Engineering Reference Values Clinical Research Humans magnetic resonance imaging Prospective Studies Child quantitative imaging biomarkers screening and diagnosis Echo-Planar Imaging Liver Diseases Liver Disease Reproducibility of Results Detection Nuclear Medicine & Medical Imaging Liver pediatric radiology Physical Sciences Elasticity Imaging Techniques Biomedical Imaging Digestive Diseases 4.2 Evaluation of markers and technologies |
| Zdroj: | Journal of magnetic resonance imaging : JMRI, vol 51, iss 3 |
| Popis: | BackgroundMagnetic resonance elastography (MRE) can determine the presence and stage of liver fibrosis. Data on normative MRE values, while reported in adults, are limited in children.PurposeTo determine the distribution of MRE-measured liver stiffness in children without liver disease.Study typeProspective, observational.PopulationEighty-one healthy children (mean 12.6 ± 2.6 years, range 8-17 years).Field strength/sequence3.0T Signa HDxt, General Electric MR Scanner; 2D GRE MRE sequence.AssessmentHistory, examination, laboratory evaluation, and (MR) exams (proton density fat fraction, PDFF, and MRE) were performed. MR elastograms were analyzed manually at two reading centers and compared with each other for agreement and with published values in healthy adults and thresholds for fibrosis in adult and pediatric patients.Statistical testsDescriptive statistics, Bland-Altman analysis, t-test to compare hepatic stiffness values with reference standards.ResultsStiffness values obtained at both reading centers were similar, without significant bias (P = 0.362) and with excellent correlation (intraclass correlation coefficient [ICC] = 0.782). Mean hepatic stiffness value for the study population was 2.45 ± 0.35 kPa (95th percentile 3.19 kPa), which was significantly higher than reported values for healthy adult subjects (2.10 ± 0.23 kPa, P |
| Databáze: | OpenAIRE |
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