The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products

Autor: Sabirova, Julia, Haddouche, R, Van Bogaert, Inge, Mulaa, F, Verstraete, Willy, Timmis, KN, Schmidt-Dannert, C, Nicaud, JM, Soetaert, Wim
Přispěvatelé: Dept Biosci & Bioengn, Ghent University [Belgium] (UGENT), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Dept Biochem, University of Nairobi (UoN), Environm Microbiol Lab, Helmholtz Centre for Infection Research (HZI), Dept Biochem Mol Biol & Biophys, University of Minnesota [Twin Cities], University of Minnesota System-University of Minnesota System, European Commission [213068], Universiteit Gent = Ghent University [Belgium] (UGENT), University of Minnesota [Twin Cities] (UMN), Gesellschaft für biotechnologische Forschung (GBF), Mascheroder Weg 1, D-38124 Braunschweig, >Germany.
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Microbial Biotechnology
Microbial Biotechnology, Wiley, 2011, 4 (1), pp.47-54. ⟨10.1111/j.1751-7915.2010.00187.x⟩
MICROBIAL BIOTECHNOLOGY
ISSN: 1751-7915
1751-7907
DOI: 10.1111/j.1751-7915.2010.00187.x⟩
Popis: The oleochemical industry is currently still dominated by conventional chemistry, with biotechnology only starting to play a more prominent role, primarily with respect to the biosurfactants or lipases, e. g. as detergents, or for biofuel production. A major bottleneck for all further biotechnological applications is the problem of the initial mobilization of cheap and vastly available lipid and oil substrates, which are then to be transformed into high-value biotechnological, nutritional or pharmacological products. Under the EU-sponsored LipoYeasts project we are developing the oleaginous yeast Yarrowia lipolytica into a versatile and high-throughput microbial factory that, by use of specific enzymatic pathways from hydrocarbonoclastic bacteria, efficiently mobilizes lipids by directing its versatile lipid metabolism towards the production of industrially valuable lipid-derived compounds like wax esters (WE), isoprenoid-derived compounds (carotenoids, polyenic carotenoid ester), polyhydroxyalkanoates (PHAs) and free hydroxylated fatty acids (HFAs). Different lipid stocks (petroleum, alkane, vegetable oil, fatty acid) and combinations thereof are being assessed as substrates in combination with different mutant and recombinant strains of Y. lipolytica, in order to modulate the composition and yields of the produced added-value products.
Databáze: OpenAIRE
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