Neurobehavioral Disturbances During Acute and Early HIV Infection
| Autor: | Kamat, Rujvi, Doyle, Katie L, Iudicello, Jennifer E, Morgan, Erin E, Morris, Sheldon, Smith, Davey M, Little, Susan J, Grant, Igor, Woods, Steven Paul, Translational Methamphetamine AIDS Research Center TMARC Group |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Inhibition (Psychology) Substance-Related Disorders Apathy neuropsychology HIV Infections Comorbidity Neuropsychological Tests Basic Behavioral and Social Science Medical and Health Sciences Cohort Studies Young Adult Executive Function motivation Clinical Research HIV Seropositivity Behavioral and Social Science Humans 2.1 Biological and endogenous factors neuropsychiatry Aetiology Retrospective Studies Inhibition Psychiatry Neurology & Neurosurgery Mood Disorders Psychology and Cognitive Sciences Neurosciences Middle Aged Mental Health Case-Control Studies Translational Methamphetamine AIDS Research Center (TMARC) Group Acute Disease Psychological HIV/AIDS Female |
| Zdroj: | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, vol 29, iss 1 Kamat, Rujvi; Doyle, Katie L; Iudicello, Jennifer E; Morgan, Erin E; Morris, Sheldon; Smith, Davey M; et al.(2016). Neurobehavioral Disturbances During Acute and Early HIV Infection.. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 29(1), 1-10. doi: 10.1097/WNN.0000000000000084. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8844424q |
| DOI: | 10.1097/WNN.0000000000000084. |
| Popis: | BACKGROUND AND OBJECTIVE:Acute and early human immunodeficiency virus infection (AEH) is accompanied by neuroinflammatory processes as well as impairment in neurocognitive and everyday functions, but little is known about the frequency and clinical correlates of the neurobehavioral disturbances during this period. We compared pre-seroconversion with current levels of apathy, disinhibition, and executive dysfunction; we also examined everyday function and HIV disease correlates of neuropsychiatric impairment in individuals with AEH. METHODS:In this study, 34 individuals with AEH and 39 HIV-seronegative participants completed neuromedical and neuropsychological assessments, a structured psychiatric interview, and the apathy, disinhibition, and executive dysfunction subscales of the Frontal Systems Behavioral Scale. RESULTS:Independent of any substance use and mood disorders, the AEH group had significantly higher levels of current apathy and executive dysfunction than the controls, but not greater disinhibition. Retrospective ratings of pre-seroconversion levels of apathy, disinhibition, and executive dysfunction were all higher in the AEH group than the controls. After seroconversion, the AEH cohort had increases in current apathy and executive dysfunction, but not disinhibition. In the AEH cohort, higher current global neurobehavioral dysfunction was significantly associated with lower nadir CD4 counts, slowed information processing speed, and more everyday function problems. CONCLUSIONS:These data suggest that individuals who have recently acquired HIV experienced higher-than-normal premorbid levels of neurobehavioral disturbance. Apathy and executive dysfunction are exacerbated during AEH, particularly in association with lower CD4 counts. |
| Databáze: | OpenAIRE |
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