Ulcerative Colitis and HLA Genes : Predisposing and Worsing Factor
| Autor: | Futami(Oouchi), Sachiko |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | 神戸大学医学部紀要. 60(2/3/4):157-166 |
| ISSN: | 0075-6431 |
| Popis: | 潰瘍性大腸炎 (ulcerative colitis : 以下UC) とHLAとの相関を, 血清学的タイピング, DNAタイピングにより検討すると共に, UCと最も強い正相関を示すDRB1^*1502対立遺伝子の有無で発症年齢, 罹患範囲, 重症度, ステロイド治療について比較検討した。UCは対照に比して, 血清学的タイピングでは, B52 (49.2% vs 19.1% ; p HLA has a strong relationship with the immune reaction as such a genetic predisposing factor of primary importance in understanding the etiology of ulcerative cilitis (UC) and the hereditary issues involved. In this study, we analyzed HLA molecules and their relationship with UC by serological typing and DNA typing, and examined any differences between DRB1*1502-positive and -negative UC patients in clinical parameters like onset age, involved extents of UC, its severity and the effectiveness of predonisolone treatment. The incidence of HLA-B52 (49.2% vs 19.1%) and DR15 (66.2% vs 32.4%), were higher in the UC patients than in the control group. DRB1^*1502 (52.3% vs 16.3%) DQA1^*0103 (53.8% vs 30.1%). DQB1^*0601 (58.5% vs 28.7%), and DPB1^*0901 (44.6% vs 16.9) were all irregularly linked, and their incidence was higher in UC patients. There was no significant relationship to onset age, extent or severity. The DRB1^*1502 positive group required more than 3g of predonisolone every year, and 5g in total. The annual dose of predonisolone was 2.4g in average in the DRB1^*1502 positive group, and only 0.48g in the DRB1^*1502 negative group. The difference between DRB1^*1501 and DRB1^*1502 is only one amino acid at position 86 of the HLA-DR β chain, that is, between α and β chain of HLA-class II molecules and affecting peptide binding. We concluded that DRB1^*1502 had a strong influence on the susceptibility to UC. |
| Databáze: | OpenAIRE |
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