pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia

Autor: Rojas de Morales, Thais, Navas, Rita, Viera, Ninoska, Álvarez, Carmen, Chaparro, Neira, Griman, Dariana
Rok vydání: 2007
Předmět:
Zdroj: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) v.12 n.6 2007
SciELO España. Revistas Científicas Españolas de Ciencias de la Salud
instname
Rojas de Morales, Thais ; Navas, Rita ; Viera, Ninoska ; Álvarez, Carmen ; Chaparro, Neira ; Griman, Dariana. pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 12 6 2007: 5
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Medicina Oral, Patología Oral y Cirugía Bucal (Internet), Volume: 12, Issue: 6, Pages: 435-439, Published: OCT 2007
Popis: Objective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To : basal condition; T1 : 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2 : 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T2 , with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1 . Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m2 Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.
Databáze: OpenAIRE
Externí odkaz: