From Patient-Specific Data to Multiscale Hemodynamics Simulations: the Challenge of Boundary Conditions
| Autor: | Vignon-Clementel, Irene, Arbia, Grégory, Baretta, Alessia, Corsini, Chiara, Esmaily Moghadam, Mahdi, Troianowski, Guillaume, Yang, Weiguang, Feinstein, Jeffrey, Hsia, T.-Y., Marsden, Alison, Migliavacca, Francesco, Pennati, Giancarlo |
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| Přispěvatelé: | Numerical simulation of biological flows (REO), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratory of biological Structure Mechanics (LaBS), Politecnico di Milano [Milan] (POLIMI), Department of Mechanical and Aerospace Engineering [Univ California San Diego] (MAE - UC San Diego), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC), Institute for Computational and Mathematical Engineering [Stanford] (ICME), Stanford University, Department of Pediatrics [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Bioengineering [Stanford], Great Ormond Street Hospital for Children [London] (GOSH), Cardiac Unit, Institute of Child Health (UCL), University College of London [London] (UCL), Leducq Foundation INRIA associated team, J. Middleton, Modeling of Congenital Hearts Alliance, Department of Mechanical and Aerospace Engineering [La Jolla] (UCSD), University of California-University of California |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP] [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] |
| Popis: | International audience; Computer fluid dynamics is now a common tool to explore hemodynamics in patient- specific simulations, either to better understand a specific physiopathology, explore several physiological states or to create a representative hemodynamics model preoperatively to explore several virtual surgical options. In this context, the specification of boundary conditions is key because pressure and flow within the modeled domain are driven by the interplay between geometry (form) and hemodynamics boundary conditions (function). However, these boundary conditions are rarely the measured variables. We thus show how one can go from patient-specific clinical data (MRI and catheterization) to simulation input parameters, including modeling assumptions and the impact of both on simulation results. To take into account the rest of the circulation outside of the three-dimensional modeled domain, a number of reduced order models exist. We explain how Windkessel models and more involved lumped parameter models can be calibrated, and discuss their predictive aspects. The specification of boundary conditions in patient-specific simulations can also create numerical challenges for which recent developments are explained. Applications include preoperative modeling and virtual surgical options in the Fontan palliation of single ventricle congenital heart disease, under rest and exercise. |
| Databáze: | OpenAIRE |
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