Analysis and design of a thrombectomy device by using simulation techniques
| Autor: | Romero Rey, Gregorio, Martínez Muneta, María Luisa, Félez Mindán, Jesús, Pearce, Gillian, Perkinson, N.D. |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Proceedings of International Conference on Innovative Methods in Product Design-IMProVe 2011 | International Conference on Innovative Methods in Product Design-IMProVe 2011 | 15/06/2011-17/06/2011 | Venecia, Italia Archivo Digital UPM Universidad Politécnica de Madrid |
| Popis: | Purpose: In this work, we present the analysis, design and optimization of one experimental device recently developed in the UK, called the 'GP' Thrombus Aspiration Device (GPTAD). This device has been designed to remove blood clots without the need to make contact with the clot itself thereby potentially reducing the risk of problems such as downstream embolisation. Method: To obtain the minimum pressure necessary to extract the clot and to optimize the device, we have simulated the performance of the GPTAD analysing the resistances, compliances and inertances effects. We model a range of diameters for the GPTAD considering different forces of adhesion of the blood clot to the artery wall, and different lengths of blood clot. In each case we determine the optimum pressure required to extract the blood clot from the artery using the GPTAD, which is attached at its proximal end to a suction pump. Result: We then compare the results of our mathematical modelling to measurements made in laboratory using plastic tube models of arteries of comparable diameter. We use abattoir porcine blood clots that are extracted using the GPTAD. The suction pressures required for such clot extraction in the plastic tube models compare favourably with those predicted by the mathematical modelling. Discussion & Conclusion: We conclude therefore that the mathematical modelling is a useful technique in predicting the performance of the GPTAD and may potentially be used in optimising the design of the device. |
| Databáze: | OpenAIRE |
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