Allylation and propargylation of chiral cyanopropanoates: An efficient route to long chain α-substituted α-methyl α-amino acids
Autor: | Cativiela, Carlos, Díaz de Villegas, María D., Gálvez, José A., Ronco, Eva |
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Přispěvatelé: | Ministerio de Ciencia y Tecnología (España), European Commission |
Rok vydání: | 2004 |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
Popis: | α-Methyllysine and 2-amino-2-methylundecanoic acid, two α,α-disubstituted unnatural glycines, were synthesized using highly diastereoselective allylation or propargylation of chiral (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyanopropanoate as the key step to introduce the long side chain. Contract grant sponsors: Ministerio de Ciencia y Tecnologia and FEDER; Contract grant number: PPQ2001-1834. |
Databáze: | OpenAIRE |
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