Plasma Streams delivery over targets relevant for biomedical applications
| Autor: | Robert, Eric, Darny, Thibault, Ries, Delphine, Dozias, Sebastien, Pouvesle, Jean-Michel |
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| Přispěvatelé: | Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), MRS, ANR-10-BLAN-0930,PAMPA,Plasmas: Microjets à Pression Atmosphérique(2010) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | 2014 MRS Fall Meeting, Symp. G Plasma processing and diagnostics for life science 2014 MRS Fall Meeting, Symp. G Plasma processing and diagnostics for life science, MRS, Nov 2014, Boston, United States |
| Popis: | International audience; GREMI develops from years the Plasma Gun non thermal plasma (NTP) source for its application in therapeutic treatments, with a special attention to cancer treatment with NTP alone or in combination with chemotherapeutic drug [1], and for its potentialities for endoscopic protocols [2]. Besides the demonstration of antitumor action both in vitro and in vivo on various tumor bearing mice, recent studies reveal the critical roles of both plasma interaction with the target (tissue or cell culture media) and of the strong influence of plasma-generated species with the rare gas (He/Ne) flow flushed across the PG discharge reactor and emerging in the ambient air gap a few millimeters above the target under treatment. Plasma impingement over conductive targets, e.g. conductive culture media/organ or skin surfaces/metallic samples, results in the generation of secondary plasma following primary plasma stream delivery through ionization wave sustained processes, leading to drastic modifications of the reactive species generation in comparison with the free jet expansion. Such secondary plasma generation reveals the key role of the persisting plasma tail or plasma column produced during primary plasma propagation which was initially not considered with sufficient care when the “plasma bullet” moniker was suggested. The second main issue concerns the strong interplay between the rare gas flow and the plasma species generated during plasma jet ionization wave propagation. Drastic modification of the rare gas flow features have been recently evidenced and characterized through Schlieren visualization and ICCD imaging [3]. The consideration of the two processes was recently shown to be especially relevant not only for the production of hydroxyl radical over conductive targets but also for the comprehensive description of OH spatial distribution using the combination of different experimental diagnostic tools (optical emission spectroscopy, laser induced fluorescence, Schlieren visualization and ICCD imaging) [4].This work is supported by the APR Region Centre PLASMEDNORM and ANR 2010 BLANC 093001 PAMPA.References[1] Brulle L, Vandamme M, Riès D, Martel E, Robert E, Lerondel S, Trichet V, Richard S, Pouvesle J M and Le Pape A., 2012, Plos one 7 (12) e52653.[2] Robert E., Vandamme M., Brullé L., Lerondel S., Le Pape A., Sarron V., Riès D., Darny T., Dozias S., Collet G., Kieda C. And Pouvesle J.M., 2013 Clin. Plasma Medicine, 1 8-16.[3] E. Robert, V. Sarron, T Darny, D. Riès, S. Dozias, J Fontane, L. Joly and J.M. Pouvesle, 2014 Plasma Sources Sci. Technol. 23 0120003.[4] Riès D., Dilecce G., Robert E., Ambrico P.F., Dozias S. and Pouvesle J.M., 2014 J.Phys.D:Appl. Phys. 47 275401. |
| Databáze: | OpenAIRE |
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