Deciphering the importance of biomarkers in colorectal and urothelial cancers in the era of precision oncology
| Autor: | Ruiz Bañobre, Juan |
|---|---|
| Přispěvatelé: | López López, Rafael, de la Fuente Freire, María, Díaz Lagares, Ángel, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina, Fuente Freire, María de la |
| Rok vydání: | 2021 |
| Předmět: |
Investigación::32 Ciencias médicas::3205 Medicina interna::320503 Gastroenterología [Materias]
biomarker Precision oncology colorectal cancer immunotherapy Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología [Materias] urothelial carcinoma Investigación::32 Ciencias médicas::3213 Cirugía::321316 Urología [Materias] |
| Zdroj: | Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| Popis: | Precision oncology is a rapidly evolving field in many different aspects. Taking this in mind and considering the central role of biomarkers in precision oncology, this thesis affords various important aspects regarding predictive and prognostic biomarkers in two important clinical scenarios. First, this thesis presents a systematic and comprehensive review on metastatic colorectal cancer that summarizes the most relevant milestones achieved in the field of predictive biomarkers to various treatments; analyzes and discusses methodological aspects, current trends, and future directions in this exciting area. Second, because of the lack of biomarkers in the context of mucinous colorectal cancer, this thesis affords the role of microRNAs from a biological and prognostic viewpoint in this specific colorectal cancer subtype. Lastly, this thesis presents a multicenter retrospective study in metastatic urothelial carcinoma patients, which investigates the safety and efficacy of immunotherapy, and explores pretreatment factors influencing therapeutic outcomes in daily clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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