Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs
| Autor: | Schuurman, Wouter, Levett, Peter A., Pot, Michiel W., van Weeren, Paul René, Dhert, Wouter J. A., Hutmacher, Dietmar W., Melchels, Ferry P. W., Klein, Travis J., Malda, Jos |
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| Přispěvatelé: | Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, Faculteit Diergeneeskunde, Onderzoek, Sub General Pharmaceutics |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Acrylamides
Compressive Strength Tissue Engineering Tissue Scaffolds Cell Survival Ultraviolet Rays Bioprinting Temperature Biocompatible Materials Hydrogels DNA Photopolymerisation Immunohistochemistry 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Cartilage Cross-Linking Reagents Materials Testing 090301 Biomaterials Animals Gelatin Horses Hyaluronic Acid Glycosaminoglycans Mechanical Phenomena |
| Zdroj: | Macromolecular Bioscience |
| Popis: | Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties. |
| Databáze: | OpenAIRE |
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