| Autor: |
Stoppacher, Sara, Scheruebel, Susanne, Üçal, Muammer, Kornmüller, Karin, Glowacki, Eric, Schindl, Rainer, Shrestha, Niroj, Schmidt, Tony, Baumgartner, Christian, Rienmüller, Theresa |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation. Funding agency: FWF Zukunftskolleg Program as part of the project“LOGOS-TBI: Light-controlled Organic Semiconductor Implants for Regeneration afterTBI” (Project ID: ZK-17) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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