Antitumoral, Antileishmanial and Antimalarial Activity of Pentacyclic 1,4-Naphthoquinone Derivatives
| Autor: | Da Silva, A. J. M., Netto, C. D., Pacienza-Lima, W., Torres-Santos, E. C., Rossi-Bergmann, B., Maurel, S., Valentin, A., Costa, P. R. R. |
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| Zdroj: | ResearcherID Scopus-Elsevier |
| Popis: | Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA). |
| Databáze: | OpenAIRE |
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