Estudio ecocardiográfico y de la concentración de NT-proBNP en pacientes diabéticos tipo 2 con y sin cardiopatía isquémica

Autor:	Castaño, S. (Sara), Coma-Canella, I. (Isabel), Lopez-Salazar, M.B. (María Begoña), Barba, J. (Joaquín)
Jazyk:	Spanish; Castilian
Rok vydání:	2009
Předmět:	Diabetes mellitus type 2/blood/complications Myocardial ischemia/blood/complications/ultrasonography cardiovascular diseases Natriuretic peptide brain/blood hormones hormone substitutes and hormone antagonists
Zdroj:	Dadun. Depósito Académico Digital de la Universidad de Navarra instname
Popis:	The aim of this study was to determine whether there are differences in echocardiographic findings or in the level of a biochemical marker (i.e. N-terminal probrain natriuretic peptide [NT-proBNP]) between controls and type-2 diabetic patients with or without ischemic heart disease. Echocardiography was used to assess left ventricular function and morphology. In addition, the plasma NT-proBNP concentration was measured. The prevalence of diastolic dysfunction was greater in diabetics without ischemic heart disease than in controls (88% vs. 74%, respectively; P< .001) and the NT-proBNP concentration was higher (350.6+/-197.8 vs. 281.7+/-190.4 fmol/mL; P< .001). Diabetics with ischemic heart disease had a higher NT-proBNP concentration than those without (720.4+/-278.1 vs. 350.6+/-197.8 fmol/mL, respectively; P< .001). An NT-proBNP concentration >490 fmol/mL had a sensitivity of 84% and a specificity of 75% for detecting ischemic heart disease in diabetics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ddee9eb25384629d70cb47ce2ba3469 https://hdl.handle.net/10171/22535 Zobrazit plný text záznamu