Substantial interobserver variation of thyroid volume and function by visual evaluation of thyroid (99m)Tc scintigraphy
| Autor: | Kerstin Soelberg, Peter Grupe, Henrik Boel-Jørgensen, Peter Jørgensen, Søren Fast, Nielsen, Viveque E., Laszlo Hegedüs, Steen Bonnema |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Soelberg, K, Grupe, P, Boel-Jørgensen, H, Jørgensen, P, Fast, S, Nielsen, V E, Hegedüs, L & Bonnema, S J 2014, ' Substantial interobserver variation of thyroid volume and function by visual evaluation of thyroid (99m)Tc scintigraphy ', Danish Medical Journal, vol. 61, no. 2, A4768 . < http://www.ncbi.nlm.nih.gov/pubmed/24495880 > University of Southern Denmark Soelberg, K K, Grupe, P, Boel-Jørgensen, H, Jørgensen, P H, Fast, S, Nielsen, V E, Hegedüs, L & Bonnema, S J 2014, ' Substantial interobserver variation of thyroid volume and function by visual evaluation of thyroid (99m)Tc scintigraphy ', Danish Medical Journal, vol. 61, no. 2, pp. A4768 . |
| Popis: | Introduction: 99mTc-pertechnetate scintigraphy is much used in the evaluation of patients with nodular goitre. We investigated the ability of experienced observers to estimate the thyroid 24-h 131I uptake (RAIU) and the thyroid volume by visual evaluation of the scintigram. Material and methods: Two endocrinologists and two nuclear medicine specialists visually evaluated thyroid scintigrams from 171 patients with nodular goitre. The variables were assessed in a blinded fashion according to predefined categories and then compared with the true values. The assessments were repeated after four weeks. Kappa (κ ω) statistics were used. Results: There was a low probability (range 6-22%) for the observers to assess the thyroid RAIU correctly. The probability of assessing the thyroid volume correctly was in the 14-22% range. Endocrinologists tended to underestimate the thyroid RAIU, mostly in patients with a RAIU > 30%. All observers significantly underestimated the thyroid volume if this was > 80 ml. There was a low interobserver agreement for the thyroid RAIU assessment (κ ω-values: 0.03- 0.43) as well as for the thyroid volume assessment (κ ω- values: 0.19-0.48). The corresponding κ ω-values for the intraobserver agreement were 0.34-0.68 and 0.37-0.62, respectively. Nuclear medicine specialists achieved a significantly higher agreement than endocrinologists in their evaluation of both thyroid parameters. Conclusion: Thyroid 99mTc scintigraphy has poor interobserver agreement and is inaccurate for assessment of quantitative thyroid parameters, even when performed by experienced specialists. |
| Databáze: | OpenAIRE |
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