Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study
| Autor: | Rezaeian, P, Miller, PE, Haberlen, SA, Razipour, A, Bahrami, H, Castillo, R, Witt, MD, Kingsley, L, Jr, PFJ, Nakanishi, R, Matsumoto, S, Alani, A, Jacobson, LP, Post, WS, Budoff, MJ |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Computed Tomography Angiography Thoracic Clinical Sciences Heart Valve Diseases Aortic Diseases HIV Infections Coronary Artery Disease Cardiorespiratory Medicine and Haematology Coronary Angiography Aortography Risk Factors HIV Seronegativity HIV Seropositivity Multidetector Computed Tomography Prevalence Odds Ratio Humans Coronary plaque morphology Prospective Studies Vascular Calcification Aorta Aged Plaque Atherosclerotic virus diseases Calcinosis HIV Inflammatory biomarkers Middle Aged Prognosis Coronary Vessels United States Logistic Models Cardiovascular System & Hematology Aortic Valve Multivariate Analysis Mitral Valve Inflammation Mediators Biomarkers Extra-coronary calcification |
| Zdroj: | Journal of cardiovascular computed tomography, vol 10, iss 3 Rezaeian, P; Miller, PE; Haberlen, SA; Razipour, A; Bahrami, H; Castillo, R; et al.(2016). Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study. JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 10(3), 229-236. doi: 10.1016/j.jcct.2016.02.002. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4t80v80x |
| DOI: | 10.1016/j.jcct.2016.02.002. |
| Popis: | IntroductionPrevious studies have demonstrated an association between HIV infection and coronary artery disease (CAD); little is known about potential associations between HIV infection and extra-coronary calcification (ECC).MethodsWe analyzed 621 HIV infected (HIV+) and 384 HIV uninfected (HIV-) men from the Multicenter AIDS Cohort Study who underwent non-contrast computed tomography (CT) from 2010-2013. Agatston scores were calculated for mitral annular calcification (MAC), aortic valve calcification (AVC), aortic valve ring calcification (AVRC), and thoracic aortic calcification (TAC). The associations between HIV infection and the presence of each type of ECC (score > 0) were evaluated by multivariable logistic regression. We also evaluated the association of ECC with inflammatory biomarker levels and coronary plaque morphology.ResultsAmong HIV+ and HIV- men, the age-standardized prevalences were 15% for TAC (HIV+ 14%/HIV- 16%), 10% for AVC (HIV+ 11%/HIV- 8%), 24% for AVRC (HIV+ 23% HIV- 24%), and 5% for MAC (HIV+ 7%/HIV- 3%). After adjustment, HIV+ men had 3-fold greater odds of MAC compared to HIV- men (OR = 3.2, 95% CI: 1.5-6.7), and almost twice the odds of AVC (1.8, 1.1-2.9). HIV serostatus was not associated with TAC or AVRC. AVRC was associated with higher Il-6 and sCD163 levels. TAC was associated with higher ICAM-1, TNF-α RII, and Il-6 levels. AVC and AVRC calcification were associated with presence of non-calcified plaque in HIV+ but not HIV- men.ConclusionHIV infection is an independent predictor of MAC and AVC. Whether these calcifications predict mortality in HIV+ patients deserves further investigation. |
| Databáze: | OpenAIRE |
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