Biology of cytokine-induced hematopoietic stem and progenitor cell mobilization
| Autor: | Kruijf, E.J.F.M. de |
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| Přispěvatelé: | Fibbe, W.E., Pel, M. van, Zwaginga, J.J., Cornelissen, J.J., Schoot, C.E. van der, Leiden University |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | None |
| Popis: | Hematopoietic stem and progenitor cells (HSPC) reside in specific niches in the bone marrow, where they are part of a complex micro-environment. Several cytokines, chemokines and small molecules are involved in mobilization of HSPC from the bone marrow towards peripheral blood. This thesis describes several studies on the mechanisms of HSPC mobilization: the kinetics of HSPC mobilization following the administration of Flt3-ligand in a murine model, the effects of repeated in vivo administration of recombinant human G-CSF and murine recombinant G-CSF in mice, the role of alpha-1-antitrypsin in steady state and during G-CSF-induced mobilization in humans and the effects of mesenchymal stromal cells on the stem cell niche in a murine model of G-CSF-induced HSPC mobilization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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