Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos
| Autor: | Gonzales, Mitzi M, Durazo-Arvizu, Ramon A, Sachdeva, Shruti, Unterman, Terry G, O'Brien, Matthew J, Gallo, Linda C, Talavera, Gregory A, Kaplan, Robert C, Cai, Jianwen, Schneiderman, Neil, Espinoza Giacinto, Rebeca A, González, Hector M, Daviglus, Martha L, Lamar, Melissa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Aging Adolescent Epidemiology Hispanics Clinical Sciences Young Adult Endocrinology & Metabolism Cognition Hyperinsulinism Behavioral and Social Science Diabetes Mellitus Humans Psychology Prospective Studies Community Health Services Latinos Metabolic and endocrine Aged Diabetes Insulin resistance Hispanic or Latino Middle Aged Prognosis Public Health and Health Services Female Hispanic Americans Cognition Disorders |
| Zdroj: | Gonzales, Mitzi M; Durazo-Arvizu, Ramon A; Sachdeva, Shruti; Unterman, Terry G; O'Brien, Matthew J; Gallo, Linda C; et al.(2019). Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos.. Diabetes research and clinical practice. doi: 10.1016/j.diabres.2019.01.030. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5gm8v5zm |
| Popis: | AimsInsulin resistance (IR) adversely impacts memory and executive functioning in non-Hispanic whites without diabetes. Less is known in Hispanics/Latinos, despite the fact that Hispanics/Latinos have higher rates of insulin resistance than non-Hispanic whites. We investigated the association between IR and cognition and its variation by age.MethodsData from 5987 participants 45-74 years old without diabetes from the Hispanic Community Health Study/Study of Latinos. IR was considered continuously using homeostasis model assessment for insulin resistance (HOMA-IR) and also dichotomized based on clinically relevant thresholds for hyperinsulinemia (fasting insulin > 84.73 pmol/L or HOMA-IR > 2.6) and sample-based norms (75th percentile of fasting insulin or HOMA-IR). Cognitive testing included the Brief Spanish English Verbal Learning Test (B-SEVLT), Verbal Fluency, and Digit Symbol Substitution.ResultsThere was 90% overlap in participant categorization comparing clinically relevant and sample-based thresholds. In separate fully-adjusted linear regression models, age modified the association between HOMA-IR and Digit Symbol Substitution (p = 0.02); advancing age combined with higher HOMA-IR levels resulted in higher scores. Age also modified the association between clinically relevant hyperinsulinemia and B-SEVLT recall (p = 0.03); with increasing age came worse performance for individuals with hyperinsulinemia.ConclusionThe relationship of IR with cognition in Hispanics/Latinos without diabetes may reflect an age- and test-dependent state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|