Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains
| Autor: | Khachou, Amira, Le Moullac-Vaidye, Béatrice, Peltier, Cécile, Breiman, Adrien, Imbert-Marcille, Marie, Ruvoën-Clouet, Nathalie, Aouni, Mahjoub, Mastouri, Maha, Chouchane, Slaheddine, Le Pendu, Jacques |
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| Přispěvatelé: | Host-Pathogen Interactions in the Regulation of Immune Responses (CRCINA-ÉQUIPE 5), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Service de virologie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Université de Nantes (UN)-Université de Nantes (UN), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université de Monastir - University of Monastir (UM), CHU Fattouma Bourguiba [Monastir] (HFB), This work was supported by a joint grant from the Agence Nationale de La Recherche and the Direction Générale de l’Offre de Soin (DGOS), France: GASTROVIM 15-0007-01to JLP and BMI, respectively. AK was supported by a PhD studentship and travel grant from the Tunisian government. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases and Therapy Journal of Infectious Diseases and Therapy, Omics Publishing Group, 2020, pp.jiaa122. ⟨10.1093/infdis/jiaa122⟩ |
| DOI: | 10.1093/infdis/jiaa122⟩ |
| Popis: | International audience; In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively. |
| Databáze: | OpenAIRE |
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