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Background: Breast cancer is the most common cancer among women and the second leading cause of cancer mortality in women today. Fine needle aspiration cytology (FNAC) has very important role in diagnosis of breast cancer. In this stUdy economic and simple method was investigated as possible supplement for improve diagnostic accuracy of cytology. Objectives: The aim of the study was to compare morphometric parameters between different types of breast cancers. Methods: Image analysis was performed by use of the Sform (Vamstec, Zagreb) software on the May-Grunwald-Giemsa (MGG) stained archive aspiration specimens of breast. 15 patients were seleaed (5 patients with invasive ductal carcinoma gradus II (IDC II ; 5 patients with invasive ductal carcinoma gradus III (IDC III) and 5 patients with invasive lobular carcinoma (ILC). 500 cells and 500 nuclei for each type of cancer were studied, total of 1500 cells and 1500 nuclei. The following parameters were investigated: area, outline, max. radius, min. radius, convex area, breadth, length, nuclear/cytoplasmatic ratio, form factor and elongation. Statistic 6, x2-test were used. Results: Morphometric analysis shown statistically significant differences (P< 0.05) betwecn following investigated groups: IDC II/ IDCIII - cell: outline, max. radius ; nucleus: area, convex area, outline ; IDC II/ILC - cell: area, convex area ; nucleus: area, outline, 3. convex area ; IDC III/ ILC cell: area, max. radius, convex area, breadth, length ; nucleus: area and convex area. Conclusion: Morphometric parameters considered individually were highly associated with type and grade of breast tumour. |
