Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction
| Autor: | Soepriatna, Arvin H, Yeh, A Kevin, Clifford, Abigail D, Bezci, Semih E, O'Connell, Grace D, Goergen, Craig J |
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| Rok vydání: | 2019 |
| Předmět: |
Male
murine Ventricular Remodeling ultrasound General Science & Technology Myocardium infarction Myocardial Infarction Cardiovascular Coronary Vessels Mice Heart Disease Models left ventricular remodelling ischaemia-reperfusion myocardial strain Animals Biomedical Imaging ischaemia–reperfusion Heart Disease - Coronary Heart Disease |
| Zdroj: | Journal of the Royal Society, Interface, vol 16, iss 160 |
| Popis: | Heart failure continues to be a common and deadly sequela of myocardial infarction (MI). Despite strong evidence suggesting the importance of myocardial mechanics in cardiac remodelling, many MI studies still rely on two-dimensional analyses to estimate global left ventricular (LV) function. Here, we integrated four-dimensional ultrasound with three-dimensional strain mapping to longitudinally characterize LV mechanics within and around infarcts in order to study the post-MI remodelling process. To induce infarcts with varying severities, we separated 15 mice into three equal-sized groups: (i) sham, (ii) 30 min ischaemia-reperfusion, and (iii) permanent ligation of the left coronary artery. Four-dimensional ultrasound from a high-frequency small animal system was used to monitor changes in LV geometry, function and strain over 28 days. We reconstructed three-dimensional myocardial strain maps and showed that strain profiles at the infarct border followed a sigmoidal behaviour. We also identified that mice with mild remodelling had significantly higher strains in the infarcted myocardium than those with severe injury. Finally, we developed a new approach to non-invasively estimate infarct size from strain maps, which correlated well with histological results. Taken together, the presented work provides a thorough approach to quantify regional strain, an important component when assessing post-MI remodelling. |
| Databáze: | OpenAIRE |
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