Parity and the risk of breast and ovarian cancer in and mutation carriers

Autor: Milne, Roger L., Osorio, Ana, Ramón Y Cajal, Teresa, Baiget, Montserrat, Lasa, Adriana, Diaz-Rubio, Eduardo, Hoya, Miguel, Caldés, Trinidad, Teulé, Alex, Lázaro, Conxi, Blanco, Ignacio, Balmaña, Judith, Sánchez-Ollé, Gessamí, Vega, Ana, Blanco, Ana, Chirivella, Isabel, Esteban Cardeñosa, Eva, Durán, Mercedes, Velasco, Eladio, Martínez De Dueñas, Eduardo, Tejada, María-Isabel, Miramar, María-Dolores, Calvo, María-Teresa, Guillén-Ponce, Carmen, Salazar, Raquel, San Román, Carlos, Urioste, Miguel, Benítez, Javier
Přispěvatelé: Grupo de Epidemiología Genética y Molecular, Programa de Genética del Cáncer Humano, Spanish National Cancer Research Center (CNIO), Grupo de Genética Humana, Programa de Genética del Cáncer Humano, Servicio de Oncología Médica, Hospital de la Santa Creu i Sant Pau, Servicio de Genética, Hospital Clínico San Carlos, Laboratorio de Oncología Molecular, Programa de Consejo Genético en Cáncer, Instituto Catalán de Oncología-IDIBELL, L'Hospitalet, Programa de Diagnóstico Molecular de Cáncer Hereditario, Instituto Catalán de Oncología-IDIBELL, Breast Cancer Center, Medical Oncology Department, Vall d'Hebron University Hospital [Barcelona], Fundación Pública Galega de Medicina Xenómica-SERGAS & Grupo de Medicina Xenómica-USC, CIBER-ER, Hospital Clínico Universitario de Valencia, Grupo de Cáncer Hereditario de la Comunidad Valenciana, Laboratorio de Biología Molecular del Servicio de Análisis Clínico, Hospital Universitario La Fe, Grupo de Genética del Cáncer, Instituto de Biología y Genética Molecular (UVa-CSIC), Consorcio Hospitalario Provincial de Castellón, Laboratorio de Genética Molecular, Hospital de Cruces, Sección de Genética Médica, Servicio de Bioquímica Clínica, Hospital Universitario Miguel Server, Unidad de Consejo Genético en Cáncer, Hospital Universitario de Elche, Centro de Investigación del Cáncer, Universidad de Salamanca, Servicio de Genética Médica, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH)-Universidad de Alcalá - University of Alcalá (UAH), Centro de Investigación Biomédica En Red de Enfermedades Raras (CIBER-ER)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2009, 119 (1), pp.221-232. ⟨10.1007/s10549-009-0394-1⟩
ISSN: 0167-6806
1573-7217
DOI: 10.1007/s10549-009-0394-1⟩
Popis: International audience; Environmental or lifestyle factors are likely to explain part of the heterogeneity in breast and ovarian cancer risk among and mutation carriers. We assessed parity as a risk modifier in 515 and 503 Spanish female carriers of mutations in and , respectively. Hazard ratios (HR) and their corresponding 95% confidence intervals (CI) were estimated using weighted Cox proportional hazards regression, adjusted for year of birth and study centre. The results for ever being parous and number of live-births were very similar for carriers of mutations in both genes. For all mutation carriers combined, the estimated HR associated with ever having had a live-birth was 0.74 (95% confidence interval [CI] = 0.55–1.01, = 0.06), and that associated with each live-birth was 0.87 (95%CI = 0.77–0.98, = 0.02). The latter association was observed only in women aged 40 and above (HR = 0.81, 95%CI = 0.70–0.94, = 0.004 vs. HR = 0.99, 95%CI = 0.83–1.18, = 0.9 for women under age 40), and this trend was highly consistently observed for carriers of mutations in each gene. There was no evidence of an association between breast cancer risk and age at first birth for parous or mutation carriers (-trend ≥ 0.3). The power to detect associations with ovarian cancer risk was much lower, especially for mutation carriers. Nevertheless, having a live-birth was associated with protection for mutation carriers (HR = 0.41, 95%CI = 0.18–0.94, = 0.03), and a strong and consistent protective effect of age at first birth was observed for parous carriers of mutations in both genes (HR = 0.65, 95%CI = 0.52–0.83
Databáze: OpenAIRE
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