Design and characterization of chitosan nanoformulations for the delivery of antifungal agents
| Autor: | Calvo, Natalia Lorena, Sreekumar, Sruthi, Svetaz, Laura Andrea, Lamas, Maria Celina, Moerschbacher, Bruno M., Leonardi, Darío |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nanotecnología
Antifungal Agents DRUG DELIVERY ANTI-FUNGAL VAGINAL CANDIDIASIS CHITOSAN NANOCAPSULES INGENIERÍAS Y TECNOLOGÍAS Nano-materiales Drug Delivery Systems purl.org/becyt/ford/2 [https] purl.org/becyt/ford/2.10 [https] BIOLOGICAL ACTIVITY Econazole TIOCONAZOLE Candidiasis Vulvovaginal ECONAZOLE NITRATE |
| Zdroj: | RepHipUNR (UNR) Universidad Nacional de Rosario instacron:UNR CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2015-3686 |
| Popis: | Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim of this research was to produce a novel chitosan nanocapsule based delivery system comprising of TIO or ECO and to study their suitability in vaginal application. These systems were characterized by their physicochemical properties, encapsulation efficiency, in vitro release, storage stability, cytotoxicity, and in vitro biological activity. Both nanocapsules loaded with TIO (average hydrodynamic size of 146.8 ± 0.8 nm, zeta potential of +24.7 ± 1.1 mV) or ECO (average hydrodynamic size of 127.1 ± 1.5 nm, zeta potential of +33.0 ± 1.0 mV) showed excellent association efficiency (99% for TIO and 87% for ECO). The analysis of size, polydispersity index, and zeta potential of the systems at 4, 25, and 37 ◦C (over a period of two months) showed the stability of the systems. Finally, the developed nanosystems presented fungicidal activity against C. albicans at non-toxic concentrations (studied on model human skin cells). The results obtained from this study are the first step in the development of a pharmaceutical dosage form suitable for the treatment of vaginal candidiasis. Para citar este articulo: Calvo, N.L.; Sreekumar, S.; Svetaz, L.A.; Lamas, M.C.; Moerschbacher, B.M.; Leonardi, D. Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents. Int. J. Mol. Sci. 2019, 20, 3686. https://doi.org/10.3390/ijms20153686 Fil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. Fil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Análisis de Medicamentos; Argentina. Fil: Sreekumar, Sruthi. Westfälische Wilhelms-Universität Münster. Institute for Biology and Biotechnology of Plants (IBBP); Germany. Fil: Svetaz, Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina. Fil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. Fil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia. Área Técnica Farmacéutica; Argentina. Fil: Moerschbacher, Bruno M. Westfälische Wilhelms-Universität Münster. Institute for Biology and Biotechnology of Plants (IBBP); Germany. Fil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. Fil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia. Área Técnica Farmacéutica; Argentina. |
| Databáze: | OpenAIRE |
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