Reduction of Weinreb amides to aldehydes under ambient conditions with magnesium borohydride reagents Dedicated to the memory of Professor Sheldon Shore
| Autor: | Bailey, CL, Clary, JW, Tansakul, C, Klabunde, L, Anderson, CL, Joh, AY, Lill, AT, Peer, N, Braslau, R, Singaram, B |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Bailey, CL; Clary, JW; Tansakul, C; Klabunde, L; Anderson, CL; Joh, AY; et al.(2015). Reduction of Weinreb amides to aldehydes under ambient conditions with magnesium borohydride reagents Dedicated to the memory of Professor Sheldon Shore. Tetrahedron Letters, 56(5), 706-709. doi: 10.1016/j.tetlet.2014.12.066. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/7f96813f Tetrahedron Letters, vol 56, iss 5 |
| DOI: | 10.1016/j.tetlet.2014.12.066. |
| Popis: | © 2014 Elsevier Ltd. All rights reserved. Chloromagnesium dimethylaminoborohydride (ClMg+[H3BNMe2]-, MgAB) is an analogue of the versatile lithium dialkylaminoborohydrides (LAB reagents), prepared by the reaction of dimethylamine-borane with methylmagnesium chloride. MgAB is a partial reducing agent for Weinreb amides under ambient conditions and is complementary to the commonly utilized lithium aluminum hydride (LiAlH4) and diisobutylaluminum hydride (DIBAL) reagents, while exhibiting enhanced chemoselectivity. To prevent over-reduction, the aldehyde products are readily isolated in good yields by forming the sodium bisulfite adducts. Aldehyde products can both be stored and later used as the bisulfite adducts, or can be regenerated from the bisulfite adducts by treatment with aqueous formaldehyde. |
| Databáze: | OpenAIRE |
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