Ambient particulate air pollution from vehicles promotes lipid peroxidation and inflammatory responses in rat lung
| Autor: | Pereira, C. E. L., Thiago Heck, Saldiva, P. H. N., Rhoden, C. R. |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 40, Iss 10, Pp 1353-1359 (2007) Brazilian Journal of Medical and Biological Research, Volume: 40, Issue: 10, Pages: 1353-1359, Published: 14 AUG 2007 Scopus-Elsevier Brazilian Journal of Medical and Biological Research v.40 n.10 2007 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | Oxidative stress plays a major role in the pathogenesis of particle-dependent lung injury. Ambient particle levels from vehicles have not been previously shown to cause oxidative stress to the lungs. The present study was conducted to a) determine whether short-term exposure to ambient levels of particulate air pollution from vehicles elicits inflammatory responses and lipid peroxidation in rat lungs, and b) determine if intermittent short-term exposures (every 4 days) induce some degree of tolerance. Three-month-old male Wistar rats were exposed to ambient particulate matter (PM) from vehicles (N = 30) for 6 or 20 continuous hours, or for intermittent (5 h) periods during 20 h for 4 consecutive days or to filtered air (PM |
| Databáze: | OpenAIRE |
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