Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 GSTT1
| Autor: | Delft, J.H.M. van, Steenwinkel, M.-J.S.T., Asten, J.G. van, Vogel, N. de, Bruijntjes-Rozier, T.C.D.M., Schouten, T., Cramers, P., Maas, L., Herwijnen, M.H. van, Schooten, F.-J. van, Hopmans, P.M.J. |
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| Přispěvatelé: | Centraal Instituut voor Voedingsonderzoek TNO |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Urine level sister-chromatid exchange [SCE] MN: micronuclei Glutathione transferase Chromosome analysis Cancer risk DNA Adducts Coke oven industry Micronucleus test Occupational Exposure SCE: sister-chromatid exchange Industry Humans 1-hydroxypyrene [1-OHpyr] Biology Comet assay Coke PAH: polycyclic aromatic hydrocarbons Priority journal Sister chromatid exchange 1-OHpyr: 1-hydroxypyrene 1 Hydroxypyrene GST: glutathione S-transferase DNA strand breakage Genetic polymorphism Polymorphism Genetic Smoking glutathione S-transferase [GST] Middle Aged polycyclic aromatic hydrocarbons [PAH] Polycyclic aromatic hydrocarbon Normal human Polycyclic Hydrocarbons Aromatic Biological monitoring Multivariate analysis Industrial worker DNA adduct cells with a high frequency of SCE [HFC] Lymphocyte Lung cancer HFC: cells with a high frequency of SCE micronuclei [MN] Controlled study Endothelium cell Human |
| Zdroj: | Annals of Occupational Hygiene, 5, 45, 395-408 |
| Popis: | Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations. Objective: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1. Methods: Urinary 1-hydroxypyrene (1-OHpyr) levels were used to monitor the internal dose, while the internal effective dose was assessed by monitoring PAH-DNA adducts, DNA strand breaks (Comet assay), sister-chromatid exchanges (SCE) and cells with a high frequency of SCE (HFC) in lymphocytes together with micronuclei (MN) in exfoliated urothelial cells. Results: Occupational exposure to PAH resulted in statistically significant increased 1-OHpyr levels (P |
| Databáze: | OpenAIRE |
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