Computer-Aided: Modelled Sustainable Hybrid Catalysts for a Nano-drug Delivery System
| Autor: | Thage, R.L., Semegni, Y., Naidoo, S. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | South African Journal of Chemistry, Volume: 73, Pages: 103-110, Published: 2020 South African Journal of Chemistry; Vol. 73 No. 1 (2020); 103–110 |
| ISSN: | 0379-4350 |
| Popis: | We evaluated a hybrid catalytic power source for less invasive internal electroporation with better tissue reach than the widely used and more invasive external electroporation. We modelled how open-circuit voltage optimizes platinum-loading in catalysts to improve the electrochemical activity (ECA) possible from bioelectrogenesis through these systems and address the high costs of nano-drug delivery systems. The effects of the catalysts' convective flux and proton concentration were modelled for an enzyme (glucose oxidase) biofuel cell that was fed glucose substrate at a current rate under isothermal physiological conditions. Glucose concentrations were varied relative to anode catalyst loading models with 0.1-0.5 mg cm-2 platinum and alloyed (Pt-Ru-Ni) with a narrow particle size distribution. Using the free (solvation) electron model, bioelectrochemical activity (BECA) and a high open circuit voltage were generated by 5.5,10 and 20 mM glucose with 20 kU L-1 glucose oxidase at 37 °C. BECA (glucose oxidase), on its own, produced pulses of various intensities for nano-microsecond durations whereas the hybrid BECA-ECA (glucose oxidase and platinum) anode catalyst provided sustainable pulses of microseconds-minute durations. Enhanced catalysis with the hybrid BECA-ECA's open circuit voltage favours compatibility of a hybrid-powered nano-drug delivery system for internal electroporation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|