| Popis: |
The majority of DNA viruses have to deliver their genome to the cell nucleus, which provi- des factors required for their replication and transcription. This work is focused on this proces of small nonenveloped DNA viruses. It describes delivery of the adenovirus, parvovirus, pa- pillomavirus and polyomavirus genomes into the cell nucleus. These viruses are endocyted by the cell and travel to the enveloped compartments. Viral particle undergoes changes afffected by surrounding environment and activity of cellular enzymes, which results in its escape from enveloped vesicle mediated by the viral proteins. Some viruses use direct interactions with cytos- keletal transport components for travelling to the cell nucleus. In most cases, viral DNA enters cell nucleus via nuclear pore complex, although the evidence of alternative mechanisms exists as well. This work focuses on early phases of the life cycle of the selected viruses and the nucleus targeting of their genomes. Understanding the mechanisms of viral DNA nuclear import may contribute to discovery of new anti-viral therapies. |
