Unlocking the Microstructure of Inhalation Blends using X-ray Microscopy
| Autor: | Parmesh Gajjar, Hrishikesh Bale, Timothy Burnett, Xizhong Chen, Elliot, James A., Herminso Villarraga Gomez, Hammond, Robert B., Hien Nguyen, Roberts, Kevin J., Ioanna Danai Styliari, Benjamin Tordoff, Philip Withers, Darragh Murnane |
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| Zdroj: | University of Manchester-PURE Gajjar, P, Bale, H, Burnett, T, Chen, X, Elliot, J A, Gomez, H V, Hammond, R, Nguyen, H, Roberts, K, Styliari, I D, Tordoff, B, Withers, P & Murnane, D 2020, Unlocking the Microstructure of Inhalation Blends using X-ray Microscopy . in Respiratory Drug Delivery 2020 . pp. 101-112, Respiratory Drug Delivery 2020 Digital, 26/04/20 . University of Hertfordshire |
| Popis: | Microstructural equivalence (Q3) for dry powder inhalers (DPIs) is complex because it involves both pre- and post-aerosolization powders and can be influenced by the DPI device and the patient’s aerosolization efficiency. In this paper, we show how advanced 3D X-ray microscopy (XRM, also known as X-ray computed tomography) techniques can provide unique microstructural insights into pre-aerosolized inhalation powders. Nano-scale XRM is used to detect differences within individual lactose particles and agglomerates, including voids and intra-agglomerate size distributions. Micro-scale XRM is used to visualize and quantify lactose fines ( |
| Databáze: | OpenAIRE |
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