Effect of methanol extract of Basella alba L. (Basellaceae) on the fecundity and testosterone level in male rats exposed to flutamide in utero
| Autor: | Nantia, E. A., Manfo, P. F. T., Beboy, N. E., Travert, C., Carreau, Serge, Monsees, T. K., Moundipa, P. F. |
|---|---|
| Přispěvatelé: | Université de Yaoundé I, Université de Caen Normandie (UNICAEN), Normandie Université (NU), Estrogènes et Reproduction, Institut National de la Recherche Agronomique (INRA), University of the Western Cape, AUF, SALF |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Andrologia Andrologia, Wiley, 2012, 44 (1), pp.38-45. ⟨10.1111/j.1439-0272.2010.01104.x⟩ |
| ISSN: | 0303-4569 1439-0272 |
| DOI: | 10.1111/j.1439-0272.2010.01104.x⟩ |
| Popis: | International audience; We evaluated the effect of the methanol extract of Basella alba (MEBa) on testosterone level and fecundity/fertility in male rats exposed in utero to flutamide an androgen receptor antagonist. For this purpose, 1.5- and 2.5 -month-old male rats exposed in utero to flutamide were treated with the MEBa (1 mg kg-1) for 2 and 1 month respectively. Five days before the end of treatment, rats were housed with females to assess their fecundity/fertility. Thereafter, rats were sacrificed and blood collected for the quantification of testosterone. Flutamide-exposed male rats showed a decrease in their ano-genital distance (AGD, P < 0.05) and were infertile. In normal (methylcellulose-exposed) animals, MEBa provoked an increase in testosterone level in 1.5- (P < 0.008) and 2.5 -month-old rats (P < 0.01) concomitantly with the improvement in their fecundity by 25%. In flutamide-exposed male rats, MEBa increased testosterone level in 1.5 -month-old rats (P < 0.001) without any effect on their fecundity; while in 2.5- month-old rats, MEBa did not affect the testosterone level but improved fecundity (by 25%) and fertility (P < 0.001). This study demonstrated the positive effect of MEBa to enhance fecundity/fertility in normal male rats and in rats exposed to the antiandrogen flutamide during their foetal life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|