| Autor: |
de Bont, J.A.M., Raab, A., Schilling, M., Martins Dos Santos, V.A.P., Arjona Antolín, R., Gutiérrez Gómez, P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Popis: |
The present invention relates to modified eukaryotic microbial cells that have been engineered for producing 1-alcohols and derivatives thereof under anoxic conditions. To this end the eukaryotic microbial cells have been modified to express enzymes of the fatty acid β-oxidation cycle in the cytosol of the cell, under anoxic conditions, in the absence of fatty acids and in the presence of a non-fatty acid carbon source. The cells are further modified to express a metabolic route for producing under anoxic conditions, acetyl-CoA from the non-fatty acid carbon source to feed into and drive the β-oxidation cycle in the bio synthetic direction and, to express termination enzymes for conversion of reaction β-oxidation cycle intermediates into the desired fermentation product. The invention further relates to anoxic processes wherein the cells are used to produce 1-alcohols or derivatives thereof. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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