Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial

Autor: Huijbers, Marloes J., Spinhoven, Philip, Spijker, Jan, Ruhe, Henricus G., van Schaik, DJ, van Oppen, Patricia, Nolen, Willem A., Ormel, Johan, Kuyken, Willem, van der Wilt, Gert Jan, Blom, Marc B. J., Schene, Aart H., Donders, A. Rogier T., Speckens, Anne E. M.
Přispěvatelé: EMGO - Mental health, Psychiatry, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: British Journal of Psychiatry, 208(4), 366-+. Royal College of Psychiatrists
The British Journal of Psychiatry, 208(4), 366-373. Cambridge University Press
Huijbers, M J, Spinhoven, P, Spijker, J, Ruhe, H G, van Schaik, DJ, van Oppen, P, Nolen, W A, Ormel, J, Kuyken, W, van der Wilt, G J, Blom, M B J, Schene, A H, Donders, A R T & Speckens, A E M 2016, ' Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial ', British Journal of Psychiatry, vol. 208, no. 4, pp. 366-+ . https://doi.org/10.1192/bjp.bp.115.168971
ISSN: 0007-1250
DOI: 10.1192/bjp.bp.115.168971
Popis: Background Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied. Aims To investigate whether MBCT with discontinuation of mADM is non-inferior to MBCT+mADM. Method A multicentre randomised controlled non-inferiority trial (ClinicalTrials.gov: NCT00928980). Adults with recurrent depression in remission, using mADM for 6 months or longer (n = 249), were randomly allocated to either discontinue (n = 128) or continue (n = 121) mADM after MBCT. The primary outcome was depressive relapse/recurrence within 15 months. A confidence interval approach with a margin of 25% was used to test non-inferiority. Key secondary outcomes were time to relapse/recurrence and depression severity. Results The difference in relapse/recurrence rates exceeded the non-inferiority margin and time to relapse/recurrence was significantly shorter after discontinuation of mADM. There were only minor differences in depression severity. Conclusions Our findings suggest an increased risk of relapse/recurrence in patients withdrawing from mADM after MBCT. Declaration of interest None. Copyright and usage (C) The Royal College of Psychiatrists 2016.
Databáze: OpenAIRE
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