Computational and Experimental Tools of miRNAs in Cancer
| Autor: | Çakmak, Esen |
|---|---|
| Přispěvatelé: | Sağlık Hizmetleri Meslek Yüksekokulu |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Middle East Journal of Cancer, Vol 11, Iss 4, Pp 381-389 (2020) |
| ISSN: | 2008-6687 2008-6709 |
| Popis: | MicroRNAs (miRNAs) are short non-protein coding and single-stranded small RNA molecules with a critical role in the regulation of gene expression. These molecules are crucial regulatory elements in diverse biological processes such as apoptosis, development, and progression. miRNA genes have been associated with various human diseases, particularly cancer, and considered as a new biomarker. After the discovery of miRNAs, many researches have focused on identifying and characterizing miRNA genes in cancer. The various expression levels of miRNAs between cancer cells and normal cells are very crucial to diagnosis, prognosis, and treatment of many cancers. Many computational and experimental tools have been employed to characterize miRNAs. However, there exist some challenges in identifying miRNA using both computational and experimental tools due to miRNA features. The present review briefly introduced miRNA biology and certain computational and experimental tools for identifying and profiling miRNAs in cancer. Furthermore, we presented the advantages and challenges of these tools. © 2020, Shriaz University of Medical Sciences. All rights reserved. |
| Databáze: | OpenAIRE |
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