Role of transforming growth factor-beta in the development of some liver diseases

Autor:	Karina Raikhelson, Karev, V. E., Marchenko, N. V., Semenov, N. V., Palgova, L. K., Baranovsky, A. Yu
Předmět:	autoimmune hepatitis pathogenesis transforming growth factor-beta fibrosis lcsh:R chronic hepatitis c lcsh:Medicine digestive system diseases primary biliary cirrhosis macrophages
Zdroj:	Scopus-Elsevier Терапевтический архив, Vol 86, Iss 2, Pp 44-48 (2014)
Popis:	AIM: To investigate the expression of transforming growth factor-beta 1 (TGF-Β1) in the liver tissue of patients with autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and chronic hepatitis C (CHC). Materials and methods. Liver biopsy specimens were histologically and immunohistologically examined in 37 patients with verified liver diseases (12 with AIH, 15 with PBC, and 10 with CHC)/RESULTS: The expression of TGF-Β1 in the non-parenchymal liver cells of the patients with AIH and PBC with liver cirrhosis was statistically significantly higher than in those without the latter (p=0.01 and p=0.04, respectively). There was a positive relationship between the stage of fibrosis and the absolute content TGF-Β1 and CD68+ cells in the portal tracts (r=0.51). The higher expression of TGF-Β1 was found in the patients with HCV and AIH than in those with PBC (р=0.03 and р
Databáze:	OpenAIRE
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