Comorbidity and age affect treatment policy for cervical cancer: a population-based study in the south of The Netherlands, 1995-2004
| Autor: | Aa, M. A., Siesling, S., Kruitwagen, R. F. P. M., Lybeert, M. L. M., Jan Willem Coebergh, Janssen-Heijnen, M. L. G. |
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| Přispěvatelé: | Faculty of Behavioural, Management and Social Sciences |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | European Journal of Gynaecological Oncology, 29, 493-8 European Journal of Gynaecological Oncology, 29, 5, pp. 493-8 Scopus-Elsevier European Journal of Gynaecological Oncology, 29(5), 493-498. S.O.G. CANADA Inc. |
| ISSN: | 0392-2936 |
| Popis: | Item does not contain fulltext OBJECTIVE: The aim of this study was to estimate the effects of age and comorbidity on the choice of treatment modalities and prognosis for patients with cervical cancer. METHODS: All patients with cervical cancer newly diagnosed between 1995 and 2004 (n=775) were selected from the population-based Eindhoven Cancer Registry. Time trends in treatment modalities and differences in treatment between older and younger patients, and those with and without comorbidity were evaluated. RESULTS: Older patients with FIGO Stages IB-IIA, elderly and those with comorbidity underwent less surgery. In multivariate survival analysis, age had independent prognostic value. For patients with FIGO Stages IB2, IIB-IVA, age affected the choice of chemoradiation significantly. According to multivariate survival analysis, comorbidity and FIGO stage were independent prognostic factors. CONCLUSION: Older patients with cervical cancer and those with comorbidity were treated less aggressively. Because of the ever-increasing role of comorbidity in clinical decision-making for increasingly older patients in the near future, development of age-specific guidelines incorporating levels and management of specific comorbidity seems warranted. |
| Databáze: | OpenAIRE |
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