behavioral effects of MK-801 in rats

Autor: Hatip-Al-Khatib, I, Bolukbasi, F
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Popis: In this study we investigated the effect of lesioning the noradrenergic systems on the behavioral effects of (5R, 10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine hydrogen maleate-MK-801, in rats. The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride-DSP4 (60 mg/kg IP). MK-801 increased the locomotor activity and rear ing. DSP4 significantly further increased the hyperlocomotor activity, circling (especially to the left side), sniffing, rolling, and falling that were induced by MK-801. These results showed that destruction of the noradrenergic system increased MK-801-hyperlocomotor activity, ataxia and stereotypy. (C) 1999 Elsevier Science Inc.
Databáze: OpenAIRE
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