Random Number Generation in HIV Disease: Associations with Neuropsychological Functions and Activities of Daily Living
| Autor: | Sheppard, David P, Woods, Steven Paul, Doyle, Katie L, Verduzco, Marizela, The HIV Neurobehavioral Research Program (HNRP) Group |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Clinical Trials and Supportive Activities HIV Infections The HIV Neurobehavioral Research Program (HNRP) Group Neuropsychological Tests Verbal fluency Executive functions Random Allocation Young Adult Clinical Research Behavioral and Social Science Activities of Daily Living Humans Psychology Attention Aged Neurosciences Middle Aged Verbal learning Everyday functioning Clinical Psychology Infectious Diseases Mental Health Case-Control Studies HIV/AIDS Female Cognitive Sciences Cognition Disorders |
| Zdroj: | Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, vol 32, iss 1 |
| Popis: | ObjectiveHIV is associated with frontostriatal dysregulation and executive dysfunction. This study evaluated whether HIV-infected individuals evidence deficits in random number generation (RNG), which is a strategic task requiring paced, rule-guided production of digits.MethodIn total, 74 HIV+ adults and 54 seronegative comparison participants completed a comprehensive research neuropsychological battery. Participants produced a random digit sequence by avoiding any order and using numbers 1 through 10 for 100 s at a pace of 1 digit/s. Outcomes included intrusions, repetitions, seriation (1-2-3-4), and cycling (median length of gaps between repeating digits).ResultsHIV disease was associated with higher levels of seriation and cycling (ps< .05) but not intrusions or repetitions (ps> .10). Among HIV+ individuals, higher seriation was associated with neuropsychological performance including poorer auditory attention, verbal learning, and delayed memory, whereas higher cycling scores were associated with poorer delayed memory and verbal fluency (ps< .05). Higher seriation also was independently associated with self-reported declines in activities of daily living (ADLs) in the HIV+ group.ConclusionsIndividuals living with HIV disease evidence moderate difficulties in inhibiting statistically unlikely non-random sequences, which showed medium associations with higher order verbal abilities and may contribute to greater declines in everyday functioning outcomes. Future studies might examine RNG's role in health behaviors such as medical decision-making or medication adherence. |
| Databáze: | OpenAIRE |
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