Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico
| Autor: | Robbiani, Davide F, Bozzacco, Leonia, Keeffe, Jennifer R, Khouri, Ricardo, Olsen, Priscilla C, Gazumyan, Anna, Schaefer-Babajew, Dennis, Avila-Rios, Santiago, Nogueira, Lilian, Patel, Roshni, Azzopardi, Stephanie A, Uhl, Lion FK, Saeed, Mohsan, Sevilla-Reyes, Edgar E, Agudelo, Marianna, Yao, Kai-Hui, Golijanin, Jovana, Gristick, Harry B, Lee, Yu E, Hurley, Arlene, Caskey, Marina, Pai, Joy, Oliveira, Thiago, Wunder, Elsio A, Sacramento, Gielson, Nery, Nivison, Orge, Cibele, Costa, Federico, Reis, Mitermayer G, Thomas, Neena M, Eisenreich, Thomas, Weinberger, Daniel M, de Almeida, Antonio RP, West, Anthony P, Rice, Charles M, Bjorkman, Pamela J, Reyes-Teran, Gustavo, Ko, Albert I, MacDonald, Margaret R, Nussenzweig, Michel C |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Mononuclear Antibodies Viral Medical and Health Sciences Antibodies Zika virus Vaccine Related Mice flavivirus vaccine Leukocytes 2.1 Biological and endogenous factors Animals Humans Viral structure Aetiology Mexico Neutralizing B-Lymphocytes dengue virus Zika Virus Infection Prevention Biological Sciences Antibodies Neutralizing Vector-Borne Diseases Good Health and Well Being Leukocytes Mononuclear Immunization Female Immunologic Memory Brazil Developmental Biology |
| Zdroj: | Cell, vol 169, iss 4 Robbiani, DF; Bozzacco, L; Keeffe, JR; Khouri, R; Olsen, PC; Gazumyan, A; et al.(2017). Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.. Cell, 169(4), 597-609.e11. doi: 10.1016/j.cell.2017.04.024. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/3tx8p9kj |
| Popis: | Antibodies to Zika virus (ZIKV) can be protective. Toexamine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (ZEDIII) binding and neutralization. Wefind that serologic reactivity to dengue 1 virus (DENV1) EDIII before ZIKV exposure is associated with increased ZIKV neutralizing titers after exposure. Antibody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of memory B cells that express the same immunoglobulin VH3-23/VK1-5 genes. These recurring antibodies cross-react with DENV1, but not other flaviviruses, neutralize both DENV1 and ZIKV, and protect mice against ZIKV challenge. Structural analyses reveal the mechanism of recognition of the ZEDIII lateral ridge by VH3-23/VK1-5 antibodies. Serologic testing shows that antibodies to this region correlate with serum neutralizing activity to ZIKV. Thus, high neutralizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans. |
| Databáze: | OpenAIRE |
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