HIV-1 drug resistance before initiation or re-initiation of first-line ART in eight regions of Mexico: a sub-nationally representative survey
| Autor: | Ávila-Ríos, Santiago, García-Morales, Claudia, Valenzuela-Lara, Marisol, Chaillon, Antoine, Tapia-Trejo, Daniela, Pérez-García, Marissa, López-Sánchez, Dulce M, Maza-Sánchez, Liliana, Del Arenal-Sánchez, Silvia J, Paz-Juárez, Héctor E, Quiroz-Morales, Verónica S, Mehta, Sanjay R, Smith, David M, León-Juárez, Eddie A, Magis-Rodríguez, Carlos, Reyes-Terán, Gustavo, HIVDR MexNet Group |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Genotype Anti-HIV Agents Drug Resistance Antiretroviral Therapy HIV Infections Microbiology Young Adult Gene Frequency Prevalence Humans Highly Active Viral Mexico DNA Pharmacology and Pharmaceutical Sciences Viral Load Good Health and Well Being Infectious Diseases Socioeconomic Factors Medical Microbiology Mutation HIV-1 HIV/AIDS Female Antimicrobial Resistance HIVDR MexNet Group Infection Sequence Analysis |
| Zdroj: | The Journal of antimicrobial chemotherapy, vol 74, iss 4 Ávila-Ríos, Santiago; García-Morales, Claudia; Valenzuela-Lara, Marisol; Chaillon, Antoine; Tapia-Trejo, Daniela; Pérez-García, Marissa; et al.(2019). HIV-1 drug resistance before initiation or re-initiation of first-line ART in eight regions of Mexico: a sub-nationally representative survey.. The Journal of antimicrobial chemotherapy, 74(4), 1044-1055. doi: 10.1093/jac/dky512. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0056x429 |
| Popis: | BACKGROUND:HIV pretreatment drug resistance (PDR) to NNRTIs in persons initiating ART is increasing in Mexico. OBJECTIVES:To compare HIV PDR in eight sub-regions of Mexico. PATIENTS AND METHODS:A large PDR survey was implemented in Mexico (September 2017-March 2018) across eight sub-regions. All larger clinics (which provide ART to 90% of all initiators) were included, allocating sample size using the probability-proportional-to-size method. Both antiretroviral-naive and prior antiretroviral-exposed persons were included. HIV PDR levels were estimated from pol Sanger sequences obtained at a WHO-designated laboratory. RESULTS:A total of 2006 participants were enrolled from 74 clinics. PDR to NNRTIs was higher than to other drug classes (P |
| Databáze: | OpenAIRE |
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