High fat diet rapidly induces brain-plasticity-related transcriptomic signature in hypothalamus: role in energy homeostasis
| Autor: | Alexandre Benani, Alexandra Cornu, Alice Krezymon, Luc Pénicaud |
|---|---|
| Přispěvatelé: | Centre des Sciences du Goût et de l'Alimentation (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Labo/service de l'auteur, Ville service, Pays service., Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Julien, Sabine, ProdInra, Migration, Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
e - homeostatic and neuroendocrine system [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering regulation of food intake and body weight [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition [SDV.IDA]Life Sciences [q-bio]/Food engineering [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering [SDV.IDA] Life Sciences [q-bio]/Food engineering integration of peripheral signal [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Federation of European Neurosciences Societies (FENS) Federation of European Neurosciences Societies (FENS), Jul 2010, Amsterdam, Netherlands. 1 p., 2010 Federation of European Neurosciences Societies (FENS), Jul 2010, Amsterdam, Netherlands HAL |
| Popis: | Poster board E12 (1 page) ; Session 203 - Food intake regulation 3 - Abstract n° 203.1 - Publication ref.: FENS Abstr., vol.5, 203.1, 2010; International audience; We have investigated the early events that are induced by a hypercaloric hyperlipidic diet in mice. The high fat diet rapidly induced metabolic imbalance, as soon as the first day, which is characterized. by a large increase in energy intake and several others metabolic alterations such as. hypercholesterolemia, and glucose intolerance. However, the diet-induced metabolic imbalance was. fully reversed after a week, suggesting that a physiological adaptive response has been then induced,. probably in order to counteract the deleterious excessive caloric intake in these normal mice. The. hypothalamus, which ensures coordination of endocrine and autonomic functions, and thus long-term. stability of the inner milieu, is of major importance in the control of food intake and energy. homeostasis. Interestingly, the hypothalamus remains "plastic" in adulthood, meaning that neuronal. networks in this structure can undergo functional or morphological remodeling aimed at integrating. modifications in environmental conditions and in physiological states. We hypothesized that brain. plasticity could occur in hypothalamus after the change in diet condition, to re-wire hypothalamic. neuronal networks that control the eating behavior to correctly fit the food intake with the energy. expenditure. By the use of a transcriptomic tool, we observed that high fat diet was associated with. numerous up-regulation of mRNA, markers of brain plasticity as soon as the first day after the change. in diet. This transcriptional modification suggests the initiation of one main feature of brain plasticity. that is synaptogenesis. Interestingly, the kinetics of molecular signature anticipates the food behavior. restoration, suggesting that a causal relation may exist. |
| Databáze: | OpenAIRE |
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