Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children : a cluster-randomized trial

Autor: Abbeddou, Souheila, Yakes Jimenez, Elizabeth, Somé, Jérome W., Ouédraogo, Jean Bosco, Brown., Kenneth H., Hess, Sonja Y.
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Diarrhea
Male
PREPUBERTAL CHILDREN
and promotion of well-being
COMPLEMENTARY FOODS
Iron
Clinical Trials and Supportive Activities
Nutritional Status
LOW-INCOME
Global Health
Pediatrics
Paediatrics and Reproductive Medicine
Double-Blind Method
Clinical Research
HOME-FORTIFICATION
STATUS INDICATORS
MICRONUTRIENT SUPPLEMENTS
RETINOL-BINDING-PROTEIN
DISPERSIBLE TABLETS
Prevalence
Medicine and Health Sciences
Humans
Pediatrics
Perinatology
and Child Health
Micronutrients
Hemoglobin
3.3 Nutrition and chemoprevention
Vitamin A
Nutrition
Retrospective Studies
Plasma zinc concentration
Pediatric
Lipid-based nutrient supplements
PLASMA
Incidence
Anemia
Hematology
Prevention of disease and conditions
Malaria
SQ-LNS
Zinc
Good Health and Well Being
Retinol-binding protein
HEMOGLOBIN CONCENTRATIONS
Dietary Supplements
Female
Biomarkers
Zdroj: BMC PEDIATRICS
BMC pediatrics, vol 17, iss 1
ISSN: 1471-2431
Popis: BackgroundWe assessed the effects of providing a package of interventions including small-quantity lipid-based nutrient supplements (SQ-LNS) containing 0, 5 or 10mg zinc and illness treatment to Burkinabe children from 9 to 18 months of age, on biomarkers of zinc, iron and vitamin A status at 18 months and compared with a non-intervention cohort (NIC).MethodsUsing a two-stage cluster randomized trial design, communities were randomly assigned to the intervention cohort (IC) or NIC, and extended family compounds within the IC were randomly assigned to different treatment groups. IC children (n = 2435) were provided with 20g SQ-LNS/d containing 0, 5 or 10mg zinc, 6mg of iron and 400μg of vitamin A along with malaria and diarrhea treatment. NIC children (n = 785) did not receive the intervention package. At 9 and 18 months, hemoglobin (Hb), zinc, iron and vitamin A status were assessed in a sub-group (n = 404). Plasma concentrations of zinc (pZC), ferritin (pF), soluble transferrin receptor (sTfR) and retinol-binding protein (RBP) were adjusted for inflammation.ResultsAt baseline, 35% of children had low adjusted pZC (8.3mg/L) and 47% had low adjusted RBP (
Databáze: OpenAIRE
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