Advances in tissue engineering through stem cell-based co-culture
| Autor: | Paschos, NK, Brown, WE, Eswaramoorthy, R, Hu, JC, Athanasiou, KA |
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| Rok vydání: | 2015 |
| Předmět: |
1.1 Normal biological development and functioning
Clinical Sciences Medical Physiology Cell Culture Techniques Biomedical Engineering regenerative medicine Bioengineering Bone and Bones Mice Underpinning research stem cells Stem Cell Research - Nonembryonic - Human Cell Adhesion Animals Humans indirect co-culture Transplantation Tissue Engineering 5.2 Cellular and gene therapies Cell Differentiation Stem Cell Research co-culture Coculture Techniques Extracellular Matrix direct co-culture Generic Health Relevance repair cellular interaction Stem Cell Research - Nonembryonic - Non-Human Development of treatments and therapeutic interventions Signal Transduction Biotechnology |
| Zdroj: | Journal of tissue engineering and regenerative medicine, vol 9, iss 5 Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, JC; & Athanasiou, KA. (2015). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 488-503. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0h521096 Paschos, NK; Brown, WE; Eswaramoorthy, R; Hu, J; & Athanasiou, KA. (2014). Advances in tissue engineering through stem cell-based co-culture. Journal of Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.1870. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/59n521v4 Journal of Tissue Engineering and Regenerative Medicine, vol 9, iss 5 |
| DOI: | 10.1002/term.1870. |
| Popis: | © 2014 John Wiley & Sons, Ltd. Stem cells are the future in tissue engineering and regeneration. In a co-culture, stem cells not only provide a target cell source with multipotent differentiation capacity, but can also act as assisting cells that promote tissue homeostasis, metabolism, growth and repair. Their incorporation into co-culture systems seems to be important in the creation of complex tissues or organs. In this review, critical aspects of stem cell use in co-culture systems are discussed. Direct and indirect co-culture methodologies used in tissue engineering are described, along with various characteristics of cellular interactions in these systems. Direct cell-cell contact, cell-extracellular matrix interaction and signalling via soluble factors are presented. The advantages of stem cell co-culture strategies and their applications in tissue engineering and regenerative medicine are portrayed through specific examples for several tissues, including orthopaedic soft tissues, bone, heart, vasculature, lung, kidney, liver and nerve. A concise review of the progress and the lessons learned are provided, with a focus on recent developments and their implications. It is hoped that knowledge developed from one tissue can be translated to other tissues. Finally, we address challenges in tissue engineering and regenerative medicine that can potentially be overcome via employing strategies for stem cell co-culture use. |
| Databáze: | OpenAIRE |
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