Relation between brown adipose tissue and measures of obesity and metabolic dysfunction in patients with cardiovascular disease

Autor: Franssens, Bas T, Hoogduin, Hans, Leiner, Tim, van der Graaf, Yolanda, Visseren, Frank L J
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Magnetic Resonance Imaging, 46(2), 497. John Wiley and Sons Inc.
ISSN: 1053-1807
Popis: PURPOSE: To evaluate whether brown adipose tissue (BAT) is present in middle-aged patients with cardiovascular comorbidities and to quantify how BAT presence associates with obesity and metabolic dysfunction. MATERIALS AND METHODS: Supraclavicular and subcutaneous adipose tissue fat-signal-fraction (FF) was determined with 1.5T water-fat magnetic resonance imaging (MRI) in 50 patients with coronary artery disease, cerebrovascular disease, or peripheral artery disease. The association between BAT presence, as measured by a higher FF difference between supraclavicular and subcutaneous adipose tissue, and obesity and metabolic dysfunction was quantified using multivariable linear regression. RESULTS: Supraclavicular adipose tissue displays a lower FF of 82.6% (interquartile range [IQR] 78.8-84.3) compared to 90.2% (IQR 87.3-91.9) in subcutaneous white adipose tissue (WAT, P
Databáze: OpenAIRE
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