Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil

Autor: Jarrah, Samar Afif, Kmetiuk, Louise Bach, Carvalho, Otávio Valério de, Sousa, Alessandra Tammy Hayakawa Ito de, Souza, Valeria Regia Franco, Nakazato, Luciano, Colodel, Edson Moleta, Santos, Andrea Pires dos, Pettan-Brewer, Christina, Hahn, Rosane Christine, Slhessarenko, Renata Dezengrini, Ubiali, Daniel Guimarães, Pereira, Asheley Henrique Barbosa, Morais, Helio Autran de, Biondo, Alexander Welker, Dutra, Valéria
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Venomous Animals and Toxins including Tropical Diseases v.28 2022
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 28, Article number: e20210074, Published: 07 MAR 2022
Popis: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. Conclusion: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.
Databáze: OpenAIRE
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