Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation

Autor: Gibert, A., Kruizinga, A.G., Neuhold, S., Houben, G.F., Canela, M.A., Fasano, A., Catassi, C.
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: American Journal of Clinical Nutrition, 1, 97, 109-116
Popis: Background: In patients with treated celiac disease (CD), the ingestion of gluten traces contained in gluten-free (GF) wheat substitutes (eg, GF bread, flour, and pasta) could cause persisting intestinal mucosal damage. Objective: The objective was to evaluate the proportion of CD patients at risk of mucosal damage due to the consumption of GF products in 4 European countries (Italy, Spain, Germany, and Norway). Design: A probabilistic modeling approach was used to assess the risk of gluten intake at the population level. The input variables were 1) consumption of GF products, 2) concentration of gluten traces in GF products determined by the sandwich R5 ELISA method, and 3) the gluten threshold for mucosal damage of 10 to 50 mg/d. Different population and product availability scenarios were examined for risk assessment. Results: The gluten content of 205 commercially available GF products ranged between
Databáze: OpenAIRE