Chimeric protein with high antimicrobial activity
| Autor: | Martínez Fernández, Beatriz, García-Suárez, María del Mar, Rodríguez González, Ana, Rodríguez, Lorena, Lavigne, Rob |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Zdroj: | Digital.CSIC: Repositorio Institucional del CSIC Consejo Superior de Investigaciones Científicas (CSIC) Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The present invention relates to a chimeric protein comprising the CHAP catalytic domain of the endolysin LysRODI from phage PhilPLA-RODI and the SH3b cell wall binding domain of the endolysin LysH5 from phage philPLA88. This chimeric protein shows an improved lytic activity again Staphylococcus sp. and a higher stability than the other endolysins of the state of the art. The invention also relates to a polynucleotide encoding the chimeric protein, and the host cell or the composition comprising the chimeric protein or the polynucleotide encoding thereof, as well as its use for the treatment and/or prevention of an infection of Staphylococcus sp, and/or for removing, inhibiting and/or preventing Staphylococcus sp. biofilm formation on abiotic surfaces, or for removing and/or preventing the Staphylococcus sp. contamination of foods and/or abiotic surfaces Consejo Superior de Investigaciones Científicas (España) A1 Solicitud de patente con informe sobre el estado de la técnica |
| Databáze: | OpenAIRE |
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