Maximal Oxygen Uptake and Ventilation Improvement Following Sacubitril-Valsartan Therapy

Autor:	Valentim Gonçalves, A, Pereira-da-Silva, T, Galrinho, A, Rio, P, Soares, RM, Feliciano, J, Ilhão Moreira, R, Silva, S, Alves, S, Capilé, E, Cruz Ferreira, R
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Aminobutyrates Tetrazoles Stroke Volume Middle Aged HSM CAR Ventricular Function Left Oxygen Angiotensin Receptor Antagonists Drug Combinations Treatment Outcome Humans Prospective Studies Heart Failure / drug therapy Aged
Zdroj:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP
Popis:	Background: Sacubitril/valsartan had its prognosis benefit confirmed in the PARADIGM-HF trial. However, data on cardiopulmonary exercise testing (CPET) changes with sacubitril-valsartan therapy are scarce. Objective: This study aimed to compare CPET parameters before and after sacubitril-valsartan therapy. Methods: Prospective evaluation of chronic heart failure (HF) patients with left ventricular ejection fraction ≤40% despite optimized standard of care therapy, who started sacubitril-valsartan therapy, expecting no additional HF treatment. CPET data were gathered in the week before and 6 months after sacubitril-valsartan therapy. Statistical differences with a p-value
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3dd08a68331fadf1bd8dcc5b1d2ac01d https://hdl.handle.net/10400.17/3533 Zobrazit plný text záznamu