Thrombocytemia as a predictor of portal hypertension in schistosomiasis
| Autor: | Souza, Marilia Rodrigues Freitas de [UNIFESP], Toledo, Carlos Fischer de [UNIFESP], Borges, Durval Rosa [UNIFESP] |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| Popis: | Sufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma -glutamyltransferase, serum alpha (2)-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included. Univ Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, Brazil Web of Science |
| Databáze: | OpenAIRE |
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