| Autor: |
Anastasiou, AD, Strafford, S, Posada-Estefan, O, Thomson, CL, Hussaein, SA, Edwards, TJ, Malinowski, M, Hondow, N, Metzger, NK, Brown, CTA, Routledge, MN, Brown, AP, Duggal, MS, Jha, A |
| Přispěvatelé: |
European Commission, EPSRC, University of St Andrews. School of Physics and Astronomy |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Anastasiou, A D, Strafford, S, Posada-Estefan, O, Thomson, C L, Hussain, S A, Edwards, T J, Malinowski, M, Hondow, N S, Metzger, N K, Brown, C T A, Routledge, M N, Brown, A P, Duggal, M S & Jha, A 2017, ' β-pyrophosphate: A potential biomaterial for dental applications ', Materials Science and Engineering C . https://doi.org/10.1016/j.msec.2017.02.116 |
| ISSN: |
0928-4931 |
| DOI: |
10.1016/j.msec.2017.02.116 |
| Popis: |
The authors acknowledge support from the sponsors of this work; the EPSRC LUMIN (EP/K020234/1) and EU-Marie-Curie-IAPP LUSTRE (324538) projects. Tooth hypersensitivity is a growing problem affecting both the young and ageing population worldwide. Since an effective and permanent solution is not yet available, we propose a new methodology for the restoration of dental enamel using femtosecond lasers and novel calcium phosphate biomaterials. During this procedure the irradiated mineral transforms into a densified layer of acid resistant iron doped β-pyrophosphate, bonded with the surface of eroded enamel. Our aim therefore is to evaluate this densified mineral as a potential replacement material for dental hard tissue. To this end, we have tested the hardness of β-pyrophosphate pellets (sintered at 1000 °C) and its mineral precursor (brushite), the wear rate during simulated tooth-brushing trials and the cytocompatibility of these minerals in powder form. It was found that the hardness of the β-pyrophosphate pellets is comparable with that of dental enamel and significantly higher than dentine while, the brushing trials prove that the wear rate of β-pyrophosphate is much slower than that of natural enamel. Finally, cytotoxicity and genotoxicity tests suggest that iron doped β-pyrophosphate is cytocompatible and therefore could be used in dental applications. Taken together and with the previously reported results on laser irradiation of these materials we conclude that iron doped β-pyrophosphate may be a promising material for restoring acid eroded and worn enamel. Postprint |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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